2024
P Schlegel, Y Yin, AS Bates, S Dorkenwald, K Eichler, P Brooks, DS Han, M Gkantia, M dos Santos, EJ Munnelly, G Badalamente, L Serratosa Capdevila, VA Sane, AMC Fragniere, L Kiassat, MW Pleijzier, T Stürner, IMF Tamimi, CR Dunne, I Salgarella, A Javier, S Fang, E Perlman, T Kazimiers, SR Jagannathan, A Matsliah, AR Sterling, S-C Yu, CE McKellar, FlyWire Consortium, M Costa, HS Seung, M Murthy, V Hartenstein, DD Bock & GSXE Jefferis Whole-brain annotation and multi-connectome cell typing of Drosophila. Nature 634, 139–152 (2024). https://doi.org/10.1038/s41586-024-07686-5
S Takemura*, KJ Hayworth*, GB Huang*, M Januszewski*, Z Lu*, EC Marin* , S Preibisch*, CS Xu*, J Bogovic, AS Champion, HSJ Cheong, M Costa, K Eichler, W Katz, C Knecht, F Li , BJ Morris, C Ordish, PK Rivlin, P Schlegel, K Shinomiya, T Stürner, T Zhao, G Badalamente, D Bailey, P Brooks, BS Canino, J Clements, M Cook, O Duclos, CR Dunne, K Fairbanks, S Fang, S Finley-May, A Francis, R George, M Gkantia, K Harrington, GP Hopkins, J Hsu, PM Hubbard, A Javier, D Kainmueller, W Korff, J Kovalyak, D Krzeminski, SA Lauchie, A Lohff, C Maldonado, EA Manley, C Mooney, E Neace, M Nichols, O Ogundeyi, N Okeoma, T Paterson, E Phillips, EM Phillips, C Ribeiro, SM Ryan, JT Rymer, AK Scott, AL Scott, D Shepherd, A Shinomiya, C Smith, N Smith, A Suleiman, S Takemura, I Talebi, IFM Tamimi, ET Trautman, L Umayam, JJ Walsh, T Yang, GM Rubin, LK Scheffer, J Funke, S Saalfeld, HF Hess, SM Plaza, GM Card, GSXE Jefferis, and S Berg (2023). A Connectome of the Male Drosophila Ventral Nerve Cord, eLife 13:RP97769.
, , , , , , , , , , , , , , , , , , , , , Systematic annotation of a complete adult male Drosophila nerve cord connectome reveals principles of functional organisation, eLife 13:RP97766.
, , , , , , , , , , , , , , Transforming descending input into behavior: The organization of premotor circuits in the Drosophila Male Adult Nerve Cord connectome, eLife 13:RP96084.
2023
Philipp Schlegel, Yijie Yin, Alexander S. Bates, Sven Dorkenwald, Katharina Eichler, Paul Brooks, Daniel S. Han, Marina Gkantia, Marcia dos Santos, Eva J. Munnelly, Griffin Badalamente, Laia Serratosa Capdevila, Varun A. Sane, Markus W. Pleijzier, Imaan F.M. Tamimi, Christopher R. Dunne, Irene Salgarella, Alexandre Javier, Siqi Fang, Eric Perlman, Tom Kazimiers, Sridhar R. Jagannathan, Arie Matsliah, Amy R. Sterling, Szi-chieh Yu, Claire E. McKellar, FlyWire Consortium, Marta Costa, H. Sebastian Seung, Mala Murthy, Volker Hartenstein, Davi D. Bock, Gregory S.X.E. Jefferis (2023) Whole-brain annotation and multi-connectome cell typing quantifies circuit stereotypy in Drosophila bioRxiv
Sven Dorkenwald, Arie Matsliah, Amy R Sterling, Philipp Schlegel, Szi-chieh Yu, Claire E. McKellar, Albert Lin, Marta Costa, Katharina Eichler, Yijie Yin, Will Silversmith, Casey Schneider-Mizell, Chris S. Jordan, Derrick Brittain, Akhilesh Halageri, Kai Kuehner, Oluwaseun Ogedengbe, Ryan Morey, Jay Gager, Krzysztof Kruk, Eric Perlman, Runzhe Yang, David Deutsch, Doug Bland, Marissa Sorek, Ran Lu, Thomas Macrina, Kisuk Lee, J. Alexander Bae, Shang Mu, Barak Nehoran, Eric Mitchell, Sergiy Popovych, Jingpeng Wu, Zhen Jia, Manuel Castro, Nico Kemnitz, Dodam Ih, Alexander Shakeel Bates, Nils Eckstein, Jan Funke, Forrest Collman, Davi D. Bock, Gregory S.X.E. Jefferis, H. Sebastian Seung, Mala Murthy, the FlyWire Consortium (2023) Neuronal wiring diagram of an adult brain bioRxiv
2022
DS Galili, GSXE Jefferis, M Costa (2022). Connectomics and the Neural Basis of Behaviour, Current Opinion in Insect Science.
A Park, V Croset, N Otto, D Agarwal, CD Treiber, E Meschi, D Sims, S Waddell (2022). Gliotransmission of D-serine promotes thirst-directed behaviors in Drosophila, Current Biology (preprint)
2021
P Schlegel*, AS Bates*, T Stürner, SR Jagannathan, N Drummond, J Hsu, L Serratosa Capdevila, A Javier, EC Marin, A Barth-Maron, IFM Tamimi, F Li, GM Rubin, SM Plaza, M Costa, G Jefferis (2021). Information flow, cell types and stereotypy in a full olfactory connectome. eLife, 10:e66018.
2020
F Li, J Lindsey, EC Marin, N Otto, M Dreher, G Dempsey, I Stark, AS Bates, MW Pleijzier, P Schlegel, A Nern, S-Y Takemura, N Eckstein, T Yang, A Francis, A Braun, R Parekh, M Costa, LK Scheffer, Y Aso, GSXE Jefferis, LF Abbott, A Litwin-Kumar, S Waddell, GM Rubin (2020). The connectome of the adult Drosophila mushroom body provides insights into function. eLife, 9:e62576.
N Otto, MW Pleijzier, IC Morgan, AJ Edmondson-Stait, KJ Heinz, I Stark, G Dempsey, M Ito, I Kapoor, J Hsu, PM Schlegel, AS Bates, F Li, M Costa, K Ito, DD Bock, GM Rubin, GSXE Jefferis, S Waddell (2020). Input connectivity reveals additional heterogeneity of dopaminergic reinforcement in Drosophila. Current Biology, S0960-9822(20)30764-8.
EC Marin, L Büld, M Theiss, T Sarkissian, RJV Roberts, R Turnbull, IMF Tamimi, MW Pleijzier, WJ Laursen, N Drummond, P Schlegel, AS Bates, F Li, M Landgraf, M Costa, DD Bock, PA Garrity, GSXE Jefferis (2020). Connectomics analysis reveals first, second, and third order thermosensory and hygrosensory neurons in the adult Drosophila brain. Current Biology, S0960-9822(20)30844-7.
AS Bates*, P Schlegel*, RJV Roberts, N Drummond, I Tamimi, R Turnbull, X Zhao, EC Marin, PD Popovici, S Dhawan, A Jamasb, A Javier, L Serratosa Capdevila, F Li, GM Rubin, S Waddell, DD Bock, M Costa, GSXE Jefferis (2020). Complete connectomic reconstruction of olfactory projection neurons in the fly brain. Current Biology, S0960-9822(20)30858-7.
AS Bates*, JD Manton*, SR Jagannathan, M Costa, P Schlegel, T Rohlfing, GSXE Jefferis (2020). The natverse, a versatile computational toolbox to combine and analyse neuroanatomical data. eLife, 9:e53350.
2019
MJ Dolan, S Frechter, AS Bates, C Dan, P Huoviala, RJV Roberts, P Schlegel, S Dhawan, R Tabano, H Dionne, C Christoforou, K Close, B Sutcliffe, B Giuliani, F Li, M Costa, G Ihrke, G Meissner, DD Bock, Y Aso, GM Rubin†, GSXE Jefferis† (2019). Neurogenetic dissection of the Drosophila innate olfactory processing center. eLife, 8:e43079.
S Frechter, AS Bates, S Tootoonian, MJ Dolan, JD Manton, A Jamasb, J Kohl, DD Bock, GSXE Jefferis (2019). Functional and Anatomical Specificity in a Higher Olfactory Centre. eLife, 8:e44590.
AS Bates, J Janssens, GSXE Jefferis and S Aerts (2019). Neuronal cell types in the fly: single-cell anatomy meets single-cell genomics. Current Opinion in Neurobiology, 56, 125-134.
2018
Z Zheng*, JS Lauritzen*, E Perlman, CG Robinson, M Nichols, D Milkie, O Torrens, J Price, CB Fisher, N Sharifi, SA Calle-Schuler, L Kmecova, IJ Ali, B Karsh, ET Trautman, J Bogovic, P Hanslovsky, GSXE Jefferis, M Kazhdan, K Khairy, S Saalfeld, RD Fetter, DD Bock (2018). A Complete Electron Microscopy Volume of the Brain of Adult Drosophila melanogaster. Cell, 174:1-14.
J Felsenberg, PF Jacob, T Walker, O Barnstedt, AJ Edmondson-Stait, MW Pleijzier, N Otto, P Schlegel, N Sharifi, E Perisse, CS Smith, JS Lauritzen, M Costa, GSXE Jefferis, DD Bock, S Waddell (2018). Integration of Parallel Opposing Memories Underlies Memory Extinction. Cell, 175, 1-14.
MJ Dolan*, G Belliart-Guérin*, AS Bates, S Frechter, A Lampin-Saint-Amaux, Y Aso, RJV Roberts, P Schlegel, A Wong, A Hammad, DD Bock, GM Rubin, T Preat, PY Plaçais, GSXE Jefferis (2018). Communication from Learned to Innate Olfactory Processing Centers Is Required for Memory Retrieval in Drosophila. Neuron, 100, 1-18.
P Huoviala, MJ Dolan*, FM Love*, S Frechter, RJV Roberts, Z Mitrevica, P Schlegel, AS Bates, Y Aso, T Rodrigues, H Cornwall, M Stensmyr, DD Bock, GM Rubin, M Costa, GSXE Jefferis (2018). Neural circuit basis of aversive odour processing in Drosophila from sensory input to descending output, bioRχiv preprint.
2017
P Schlegel*, M Costa*, GSXE Jefferis (2017) Learning from Connectomics on the fly. Current Opinion in Insect Science, 24:96–105.
E Marin & M Costa (2017). Sensory Neurobiology: Wet Fly Fishing. Current Biology, 27:R833–R852.
Through Collaboration:
Sven Dorkenwald, Arie Matsliah, Amy R. Sterling, Philipp Schlegel, Szi-chieh Yu, Claire E. McKellar, Albert Lin, Marta Costa, Katharina Eichler, Yijie Yin, Will Silversmith, Casey Schneider-Mizell, Chris S. Jordan, Derrick Brittain, Akhilesh Halageri, Kai Kuehner, Oluwaseun Ogedengbe, Ryan Morey, Jay Gager, Krzysztof Kruk, Eric Perlman, Runzhe Yang, David Deutsch, Doug Bland, Marissa Sorek, Ran Lu, Thomas Macrina, Kisuk Lee, J. Alexander Bae, Shang Mu, Barak Nehoran, Eric Mitchell, Sergiy Popovych, Jingpeng Wu, Zhen Jia, Manuel A. Castro, Nico Kemnitz, Dodam Ih, Alexander Shakeel Bates, Nils Eckstein, Jan Funke, Forrest Collman, Davi D. Bock, Gregory S. X. E. Jefferis, H. Sebastian Seung, Mala Murthy & The FlyWire Consortium Neuronal wiring diagram of an adult brain. Nature 634, 124–138 (2024). https://doi.org/10.1038/s41586-024-07558-y
N Eckstein, AS Bates, M Du, V Hartenstein, GSXE Jefferis, J Funke (2020). Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila. bioRχiv preprint.
LK Scheffer, CS Xu,
J Buhmann, A Sheridan, S Gerhard, R Krause, T Nguyen, L Heinrich, P Schlegel, W-C A Lee, R Wilson, S Saalfeld, G Jefferis, D Bock, S Turaga, M Cook, J Funke (2019). Automatic detection of synaptic partners in a whole-brain Drosophila EM dataset. bioRχiv preprint.
PH Li , LF Lindsey, M Januszewski, Z Zheng, AS Bates, I Taisz, M Tyka, M Nichols, F Li, E Perlman, J Maitin-Shepard, T Blakely, L Leavitt, GSXE Jefferis, DD Bock, V Jain (2019). Automated Reconstruction of a Serial-Section EM Drosophila Brain with Flood-Filling Networks and Local Realignment. bioRχiv preprint.
S Sayin, J-F De Backer, ME Wosniack, L Lewis, KP Siju, L-M Frisch, P Schlegel, A Edmondson-Stait, N Sharifi, CB Fisher, SA Calle-Schuler, S Lauritzen, DD Bock, M Costa, GSXE Jefferis, J Gjorgjieva, I Grunwald Kladow (2019). A neural circuit arbitrates between perseverance and withdrawal in hungry Drosophila. Neuron 104:3, 544-558.
Relevant Publications from Team Members:
M Costa, JD Manton, AD Ostrovksy, S Prohaska, GSXE Jefferis (2016). NBLAST: Rapid, Sensitive Comparison of Neuronal Structure and Construction of Neuron Family Databases. Neuron, 91(2):293-311.
Highlighted authors were funded by the Wellcome Trust.
* these authors contributed equally